Even if you get a portable version to launch, editing SharePoint 2010 sites requires connecting to a live SharePoint 2010 server. Since SharePoint 2010 reached , such environments are rare outside legacy systems.
: Windows 7 SP1, Windows 8, or Windows 10/11 (may require enabling .NET Framework 3.5 in Windows Features). Processor : 500 MHz or higher. Memory : 256 MB RAM minimum. Storage : 2.5 GB available disk space. Key Features of the 2010 Version: microsoft+sharepoint+designer+2010+64bit+portable
Microsoft SharePoint Designer 2010 64-bit: The Search for a Portable Version Even if you get a portable version to
Microsoft never compiled SPD 2010 as a native 64-bit application. All official downloads from MSDN, TechNet, and the Microsoft Download Center delivered a 32-bit executable. microsoft+sharepoint+designer+2010+64bit+portable