Resident Evil 4 - Disc 2 - Romsmania -

Your Disc 2 ROM may be corrupted. Re-download from RomsMania and verify the MD5 checksum. A healthy GameCube Disc 2 should have MD5: a1b2c3d4e5f67890... (check Reddit for current hash).

Keeping each ISO in a separate folder can sometimes help avoid file path errors in certain mobile emulators. Resident Evil 4 - Disc 2 - RomsMania