Future updates to Uncharted 4 (if any) will likely break both fixes. Block the game from updating via Steam’s “Only update this game when I launch it” setting, and always launch via your .bat file or patched EXE.
Even though Uncharted 4 has no invasive anti-cheat, Steam’s "Steam Input" overlay can conflict with the proxy DLL. Disable the Steam Overlay for this game. uncharted 4 avx2 fix
Before the official patch, and for some specific legacy configurations, users explored several manual methods: Future updates to Uncharted 4 (if any) will