Corrupted engine files can prevent the display mode from being set correctly. Right-click in your Steam Library. Select Properties > Local Files .
The settings file might have corrupt or incompatible video parameters.
The in Serious Sam 3: BFE
If deleting the INI file didn’t work, the game might still be trying to force an unsupported fullscreen resolution. The solution is to force the game to start in . Once inside, you can change the resolution and switch back to fullscreen.